TRPM2

TRPM2
Identifiers
Aliases TRPM2, Trpm2, 9830168K16Rik, C79133, LTRPC2, TRPC7, Trp7, Trrp7, EREG1, KNP3, NUDT9H, NUDT9L1, LTrpC-2, transient receptor potential cation channel subfamily M member 2
External IDs MGI: 1351901 HomoloGene: 20709 GeneCards: TRPM2
Targeted by Drug
cyclic adp-ribose, hydrogen peroxide, NAADP, arachidonic acid, 2-aminoethoxydiphenylborate, clotrimazole, econazole, flufenamic acid, miconazole, Hydron[1]
Orthologs
Species Human Mouse
Entrez

7226

28240

Ensembl

ENSG00000142185

ENSMUSG00000009292

UniProt

O94759

Q91YD4

RefSeq (mRNA)

NM_001001188
NM_003307
NM_001320350
NM_001320351
NM_001320352

NM_138301

RefSeq (protein)

NP_003298.1
NP_001307279.1
NP_001307280.1

n/a

Location (UCSC) Chr 21: 44.35 – 44.44 Mb Chr 10: 77.91 – 77.97 Mb
PubMed search [2] [3]
Wikidata
View/Edit HumanView/Edit Mouse

Transient receptor potential cation channel, subfamily M, member 2, also known as TRPM2, is a protein that in humans is encoded by the TRPM2 gene.

Function

The TRPM2 gene is highly expressed in the brain and was implicated by both genetic linkage studies in families[4] and then by case control or trio allelic association studies in the genetic aetiology of bipolar affective disorder (Manic Depression).[5][6]

The physiological role of TRPM2 is not well understood. It was shown to be involved in insulin secretion.[7][8] In the immune cells it mediates parts of the responses to TNF-alpha.[9] A role has been suggested for TRPM2 in activation of NLRP3 inflammasome, the dysregulation of which is strongly associated with a number of auto inflammatory and metabolic diseases, such as gout, obesity and diabetes.[10] In the brain it is involved in the toxicity of amyloid beta, a protein associated with Alzheimer's disease.[11]

Structure

The protein encoded by this gene is a non-selective calcium-permeable cation channel and is part of the Transient Receptor Potential ion channel super family. The closest relative is the cold and menthol activated TRPM8 ion channel. While TRPM2 is not cold sensitive it is activated by heat.[7] The TRPM2 ion channel is activated by free intracellular ADP-ribose in synergy with free intracellular calcium.[12] ADP-Ribose is produced to by the enzyme PARP in response to oxidative stress and confers susceptibility to cell death. Several alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known.[13]

See also

References

  1. ↑ "Drugs that physically interact with Transient receptor potential cation channel subfamily M member 2 view/edit references on wikidata".
  2. ↑ "Human PubMed Reference:".
  3. ↑ "Mouse PubMed Reference:".
  4. ↑ Gurling H (1998). "Chromosome 21 workshop". Psychiatric Genetics. 8 (2): 109–13. doi:10.1097/00041444-199800820-00015. PMID 9686433.
  5. ↑ McQuillin A, Bass NJ, Kalsi G, Lawrence J, Puri V, Choudhury K, Detera-Wadleigh SD, Curtis D, Gurling HM (Feb 2006). "Fine mapping of a susceptibility locus for bipolar and genetically related unipolar affective disorders, to a region containing the C21ORF29 and TRPM2 genes on chromosome 21q22.3". Molecular Psychiatry. 11 (2): 134–42. doi:10.1038/sj.mp.4001759. PMID 16205735.
  6. ↑ Xu C, Macciardi F, Li PP, Yoon IS, Cooke RG, Hughes B, Parikh SV, McIntyre RS, Kennedy JL, Warsh JJ (Jan 2006). "Association of the putative susceptibility gene, transient receptor potential protein melastatin type 2, with bipolar disorder". American Journal of Medical Genetics Part B. 141B (1): 36–43. doi:10.1002/ajmg.b.30239. PMID 16252251.
  7. 1 2 Togashi K, Hara Y, Tominaga T, Higashi T, Konishi Y, Mori Y, Tominaga M (May 2006). "TRPM2 activation by cyclic ADP-ribose at body temperature is involved in insulin secretion". The EMBO Journal. 25 (9): 1804–15. doi:10.1038/sj.emboj.7601083. PMC 1456947Freely accessible. PMID 16601673.
  8. ↑ Bari MR, Akbar S, Eweida M, Kühn FJ, Gustafsson AJ, Lückhoff A, Islam MS (Sep 2009). "H2O2-induced Ca2+ influx and its inhibition by N-(p-amylcinnamoyl) anthranilic acid in the beta-cells: involvement of TRPM2 channels". Journal of Cellular and Molecular Medicine. 13 (9B): 3260–7. doi:10.1111/j.1582-4934.2009.00737.x. PMC 4516483Freely accessible. PMID 19382906.
  9. ↑ Yamamoto S, Shimizu S, Kiyonaka S, Takahashi N, Wajima T, Hara Y, Negoro T, Hiroi T, Kiuchi Y, Okada T, Kaneko S, Lange I, Fleig A, Penner R, Nishi M, Takeshima H, Mori Y (Jul 2008). "TRPM2-mediated Ca2+influx induces chemokine production in monocytes that aggravates inflammatory neutrophil infiltration". Nature Medicine. 14 (7): 738–47. doi:10.1038/nm1758. PMC 2789807Freely accessible. PMID 18542050.
  10. ↑ Zhong Z, Zhai Y, Liang S, Mori Y, Han R, Sutterwala FS, Qiao L (2013). "TRPM2 links oxidative stress to NLRP3 inflammasome activation". Nature Communications. 4: 1611. doi:10.1038/ncomms2608. PMC 3605705Freely accessible. PMID 23511475.
  11. ↑ Miller BA (Jan 2006). "The role of TRP channels in oxidative stress-induced cell death". The Journal of Membrane Biology. 209 (1): 31–41. doi:10.1007/s00232-005-0839-3. PMID 16685599.
  12. ↑ Csanády L, Törocsik B (Feb 2009). "Four Ca2+ ions activate TRPM2 channels by binding in deep crevices near the pore but intracellularly of the gate". The Journal of General Physiology. 133 (2): 189–203. doi:10.1085/jgp.200810109. PMC 2638199Freely accessible. PMID 19171771.
  13. ↑ "Entrez Gene: TRPM2 transient receptor potential cation channel, subfamily M, member 2".

Further reading

  • Clapham DE, Julius D, Montell C, Schultz G (Dec 2005). "International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels". Pharmacological Reviews. 57 (4): 427–50. doi:10.1124/pr.57.4.6. PMID 16382100. 
  • Eisfeld J, Lückhoff A (2007). "TRPM2". Handbook of Experimental Pharmacology. Handbook of Experimental Pharmacology. 179 (179): 237–52. doi:10.1007/978-3-540-34891-7_14. ISBN 978-3-540-34889-4. PMID 17217061. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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