5α-Dihydrocorticosterone
 | |
| Names | |
|---|---|
| IUPAC name
(5S,8S,9S,10S,11S,13S,14S,17S)-11-Hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-3-one | |
| Identifiers | |
| 298-25-9 | |
| 3D model (Jmol) | Interactive image |
| ChemSpider | 2338305 |
| PubChem | 3080546 |
| |
| |
| Properties | |
| C21H32O4 | |
| Molar mass | 348.47638 g/mol |
| Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
| Infobox references | |
5α-Dihydrocorticosterone ((5α,11β)-11,21-dihydroxypregnane-3,20-dione; abbreviated as 5α-DHC, 5α-DHB) is a naturally-occurring, endogenous glucocorticoid steroid hormone and neurosteroid.[1][2][3] It is biosynthesized from corticosterone by the enzyme 5α-reductase.[4][5][6] DHC has central depressant effects and impairs long-term potentiation in animals.[7][8]
See also
- Tetrahydrocorticosterone
- 5α-Dihydroprogesterone
- Dihydrodeoxycorticosterone
- Tetrahydrodeoxycorticosterone
- Allopregnanolone
References
- ↑ R.A. Hill; H.L.J. Makin; D.N. Kirk; G.M. Murphy (23 May 1991). Dictionary of Steroids. CRC Press. pp. 218–. ISBN 978-0-412-27060-4.
- ↑ McInnes, K. J.; Kenyon, C. J.; Chapman, K. E.; Livingstone, D. E. W.; Macdonald, L. J.; Walker, B. R.; Andrew, R. (2004). "5 -Reduced Glucocorticoids, Novel Endogenous Activators of the Glucocorticoid Receptor". Journal of Biological Chemistry. 279 (22): 22908–22912. doi:10.1074/jbc.M402822200. ISSN 0021-9258. PMID 15044432.
- ↑ Magnaghi V (2007). "GABA and neuroactive steroid interactions in glia: new roles for old players?". Curr Neuropharmacol. 5 (1): 47–64. doi:10.2174/157015907780077132. PMC 2435342
. PMID 18615153. - ↑ Abraham Weizman (1 February 2008). Neuroactive Steroids in Brain Function, Behavior and Neuropsychiatric Disorders: Novel Strategies for Research and Treatment. Springer Science & Business Media. pp. 48–. ISBN 978-1-4020-6854-6.
- ↑ Neurosteroids and Brain Function. Academic Press. 12 December 2001. pp. 147–. ISBN 978-0-08-054423-6.
- ↑ N. Kato; M. Kawata; R.K. Pitman (3 July 2007). PTSD: Brain Mechanisms and Clinical Implications. Springer Science & Business Media. pp. 125–. ISBN 978-4-431-29567-9.
- ↑ Dubrovsky, B.; Williams, D.; Kraulis, I. (1985). "Effects of corticosterone and 5?-dihydrocorticosterone on brain excitability in the rat". Journal of Neuroscience Research. 14 (1): 117–128. doi:10.1002/jnr.490140111. ISSN 0360-4012.
- ↑ Dubrovsky, B.O.; Liquornik, M.S.; Noble, P.; Gijsbers, K. (1987). "Effects of 5α-dihydrocorticosterone on evoked responses and long-term potentiation". Brain Research Bulletin. 19 (6): 635–638. doi:10.1016/0361-9230(87)90049-9. ISSN 0361-9230.
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