FZD8

FZD8
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
Aliases FZD8, FZ-8, hFZ8, frizzled class receptor 8
External IDs MGI: 108460 HomoloGene: 40606 GeneCards: FZD8
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez

8325

14370

Ensembl

ENSG00000177283

ENSMUSG00000036904

UniProt

Q9H461

Q61091

RefSeq (mRNA)

NM_031866

NM_008058

RefSeq (protein)

NP_114072.1

NP_032084.2

Location (UCSC) Chr 10: 35.64 – 35.64 Mb Chr 18: 9.21 – 9.22 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

Frizzled-8 is a protein that in humans is encoded by the FZD8 gene.[3][4]

Function

This intronless gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This gene is highly expressed in two human cancer cell lines, indicating that it may play a role in several types of cancer. The crystal structure of the extracellular cysteine-rich domain of a similar mouse protein has been determined.[4]

See also

References

  1. "Human PubMed Reference:".
  2. "Mouse PubMed Reference:".
  3. Saitoh T, Hirai M, Katoh M (Apr 2001). "Molecular cloning and characterization of human Frizzled-8 gene on chromosome 10p11.2". Int J Oncol. 18 (5): 991–6. doi:10.3892/ijo.18.5.991. PMID 11295046.
  4. 1 2 "Entrez Gene: FZD8 frizzled homolog 8 (Drosophila)".

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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